Several studies have reported on the clinical applications, therapeutic benefits and safety of Curcumin, Aloe Vera and Elderberry, the key ingredients of PeriogGold Gel. Citations of select scientific articles on the therapeutic effectiveness and safety of these ingredients are outlined.  

Independent laboratory research on PerioGold Gel is currently being conducted at the University of Western Australia, Perth, Australia. The results of this research will be published in early 2024.

 

 

Curcumin

Trigo-Gutierrez JK, Vega-Chacón Y, Soares AB, Mima EGO. Antimicrobial Activity of Curcumin in Nanoformulations: A Comprehensive Review. Int J Mol Sci. 2021 Jul 1;22(13):7130.

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Khosrojerdi M, Gumpricht E, Jamialahmadi T, Kesharwani P, Sahebkar A. Is Curcumin a Safe and Effective Therapeutic in the Treatment against Oral Lichen Planus? Curr Med Chem. 2023;30(15):1684-1688.

 

Li Y, Jiao J, Qi Y, Yu W, Yang S, Zhang J, Zhao J. Curcumin: A review of experimental studies and mechanisms related to periodontitis treatment. J Periodontal Res. 2021 Oct;56(5):837-847.

 

Forouzanfar F, Forouzanfar A, Sathyapalan T, Orafai HM, Sahebkar A. Curcumin for the Management of Periodontal Diseases: A Review. Curr Pharm Des. 2020;26(34):4277-4284.

 

Anwar SK, Elmonaem SNA, Moussa E, Aboulela AG, Essawy MM. Curcumin nanoparticles: the topical antimycotic suspension treating oral candidiasis. Odontology. 2023 Apr;111(2):350-359.

 

Dharman S, G M, Shanmugasundaram K, Sampath RK. A Systematic Review and Meta-Analysis on the Efficacy of Curcumin/Turmeric for the Prevention and Amelioration of Radiotherapy/Radiochemotherapy Induced Oral Mucositis in Head and Neck Cancer Patients. Asian Pac J Cancer Prev. 2021 Jun 1;22(6):1671-1684. 

 

Mahin T, Torab A, Negahdari R, Maleki Dizaj S, Sharifi S. The Antibacterial Effects of Healing Abutments Coated with Gelatincurcumin Nanocomposite. Pharm Nanotechnol. 2023;11(4):390-395.

 

Ahrari F, Ramezanian N, Ahmadi Z, Mohammadipour HS. Introducing and assessing the efficacy of a novel method to reduce enamel damage after orthodontic bracket removal using two herbal-based resin colouring agents: An in vitro study. Int Orthod. 2023 Jun;21(2):100744.

 

 

Aloe Vera

Jain S, Rathod N, Nagi R, Sur J, Laheji A, Gupta N, Agrawal P, Prasad S. Antibacterial Effect of Aloe Vera Gel against Oral Pathogens: An In-vitro Study. J Clin Diagn Res. 2016 Nov;10(11):ZC41-ZC44.

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Bhat G, Kudva P, Dodwad V. Aloe vera: Nature's soothing healer to periodontal disease. J Indian Soc Periodontol. 2011 Jul;15(3):205-9.

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Kamath DG, Nadimpalli H, Nayak SU, Rajendran V, Natarajan S. Comparison of antiplaque and anti-gingivitis effects of aloe vera mouthwash with chlorhexidine in fixed orthodontic patients-A randomized controlled trial. Int J Dent Hyg. 2023 Feb;21(1):211-218.

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Yousef NJ, Aljoujou AA, Mashlah AM, Hajeer MY. Assessment of the Effectiveness of Aloe vera Versus Amlexanox in the Treatment of Recurrent Aphthous Ulcers: A Three-Arm Placebo-Controlled Randomized Clinical Trial. Cureus. 2022 Oct 26;14(10):e30693.

 

Comparative Efficacy and Safety of Interventions for the Leong XY, Gopinath D, Syeed SM, Veettil SK, Shetty NY, Menon RK. Comparative Efficacy and Safety of Interventions for the Treatment of Oral Lichen Planus: A Systematic Review and Network Meta-Analysis. J Clin Med. 2023 Apr 7;12(8):2763.

 

 

Elderberry

Harokopakis E, Albzreh MH, Haase EM, Scannapieco FA, Hajishengallis G. Inhibition of proinflammatory activities of major periodontal pathogens by aqueous extracts from elderflower (Sambucus nigra). J Periodontol. 2006 Feb;77(2):271-9.

 

Mocanu ML, Amariei S. Elderberries-A Source of Bioactive Compounds with Antiviral Action. Plants (Basel). 2022 Mar 10;11(6):740.